Effects of aflatoxin B/sub 1/ on distribution of Fe, Cu, Zn, and Mn in rat tissues

Journal Article · Sat Jan 01 00:00:00 EST 1977 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01685260· OSTI ID:7100330

Doyle, J J; Stearman, III, W C; Norman, J O; Petersen, H D.V.

The role of aflatoxin B/sub 1/ in trace element metabolism in animals is investigated. Two experiments were conducted using atomic absorption for determining the distribution of Fe, Cu, Zn, and Mn in liver, kidney, spleen, and pancreas. The results indicated body weight loss during aflatoxicosis is dose related and may be due in part to reduced body fat. It remains to be determined whether the redistribution of the metals, especially the massive influx of Fe into the liver, is the actual toxic factor in aflatoxicosis that leads to sickness and death. The preliminary results reported indicate that the effect is a complex problem involving not only a redistribution of the metals but possibly some hormonal action as well. (CAJ)

• Research Organization: Dept. of Agriculture, College Station, TX
• OSTI ID: 7100330
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 17:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AFLATOXIN
BIOLOGICAL EFFECTS
COPPER
METABOLISM
IRON
MANGANESE
ZINC
BIOLOGICAL STRESS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
HORMONES
KIDNEYS
LIVER
MORTALITY
PANCREAS
SPLEEN
TRACE AMOUNTS
WEIGHT
BODY
DIGESTIVE SYSTEM
ENDOCRINE GLANDS
GLANDS
METALS
ORGANS
TRANSITION ELEMENTS
550500* - Metabolism