In vivo distribution of liposome encapsulated hemoglobin studied with imaging radiotracers. Progress report

Technical Report · Tue Dec 01 00:00:00 EST 1992

OSTI ID:7063045

Phillips, W T

This project has as its objective the development of radiotracer imaging technology to follow the in vivo circulation and organ deposition of liposome encapsulated hemoglobin (LEH). LEH will be labeled with technetium-99m or indium-111 and infused into small animals to monitor any in vivo differences between different LEH formulations. These studies will be correlated with any hematological and pathological changes associated with LEH treatment. Development of such non-invasive monitoring techniques may lead to significant cost effective manufacturing and formulation improvements, and ultimately a more efficacious LEH product. The development of this elegant labeling technique should make it possible to study the effect of various LEH modifications on biodistribution non-invasively in primates and humans.

• Research Organization: Texas Univ., San Antonio, TX (United States)
• OSTI ID: 7063045
• Report Number(s): AD-A-258750/9/XAB; CNN: N00014-91-J-1217
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
PATHOLOGICAL CHANGES
HEMOGLOBIN
ENCAPSULATION
LIPOSOMES
DIAGNOSTIC USES
MEASURING INSTRUMENTS
DESIGN
COST
HEMATOLOGY
IMAGES
IN VIVO
INDIUM 111
LABELLED COMPOUNDS
MONITORING
PRIMATES
PROGRESS REPORT
RADIOBIOLOGY
TECHNETIUM
BETA DECAY RADIOISOTOPES
BIOLOGY
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DOCUMENT TYPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
GLOBINS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
METALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RADIOISOTOPES
TRANSITION ELEMENTS
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics