Occupational risks of pesticide exposure for females. Final report. Report for 1 September 1988-31 May 1992
The effects of exposure to methoxychlor (72435) (MXC) on reproductive functions in nonpregnant and pregnant mice were studied. Sexually mature virgin female CD-1-mice were exposed to 1.25, 2.5, or 5.0 milligrams (mg) MXC via oral gavage for 5 consecutive days each week for either 2 or 4 weeks. A dose dependency of MXC was noted in inducing persistent vaginal estrus. Ovaries of MXC and estradiol-17beta (E-17beta) exposed mice weighed significantly less than controls. There was also an increase in the number of atretic large follicles in the E-17beta group and in those mice treated with the two highest doses of MXC, indicating a potential reduction in the immediate fertility of the mice. Increased lipid accumulation was noted in interstitial cells and theca cells of both E-17beta treated and 5.0 mg MXC treated mice. The chemical appears to closely mimic the effects on the female ovary induced by estrogen and raises concern whether such an exposure of an adult female will interfere with the normal hormonal environment and thus jeopardize future pregnancy. These alterations appear to be reversible once exposure stops. Results revealed a significant increase in the length of gestation of mice exposed to both E-17beta and 5.0 mg MXC.
- Research Organization:
- Louisiana State Univ., New Orleans, LA (United States). Medical Center
- OSTI ID:
- 7061498
- Report Number(s):
- PB-93-137040/XAB; CNN: R01-OH-00835
- Resource Relation:
- Other Information: See also PB--89-200943
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
PESTICIDES
TOXICITY
BIOLOGY
CHEMICAL ANALYSIS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ESTRADIOL
FEMALES
FERTILITY
FUNCTIONAL ANALYSIS
FUNCTIONS
MICE
OCCUPATIONAL EXPOSURE
OVARIES
PREGNANCY
REPRODUCTION
RESEARCH PROGRAMS
SEX DEPENDENCE
ANIMALS
BODY
ESTRANES
ESTROGENS
FEMALE GENITALS
GONADS
HORMONES
HYDROXY COMPOUNDS
MAMMALS
MATHEMATICS
ORGANIC COMPOUNDS
ORGANS
RODENTS
STEROID HORMONES
STEROIDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology