Alpha adrenergic receptor mediation of cardiovascular and metabolic responses to alcohol

Conference · Wed Feb 26 00:00:00 EST 1992 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:7049915

Brackett, D J; Gauvin, D V; Lerner, M R; Holloway, F H; Wilson, M F ^[1]

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1. Univ. of Oklahoma, Oklahoma City (United States) Veterans Affairs Medical Center, Oklahoma City, OK (United States)

The role of alpha adrenergic receptors in acute cardiovascular and metabolic responses to alcohol (ETOH) have not been clearly defined. In this study two groups of male Sprague-Dawley rats were given intravenous phentolamine mesylate or saline prior to intragastric alcohol to blockade of alpha receptors during alcohol intoxication in conscious rats. ETOH alone evoked an increase in systemic vascular resistance (SVR), heart rate (HR), and blood glucose concentrations (G) and a decrease in mean arterial pressure (MAP), cardiac output (CO), central venous pressure (CVP), respiration rate (RR) and cardiac stroke volume (SV). Blood alcohol concentration (BAC) peaked at 30 min and remained elevated for the four hrs of monitoring. Phentolamine pretreatment produced a decrease in MAP and SV and an increase in HR. However, antagonism of the alpha receptor blocked the decrease in CO and the increase in SVR and G. The decrease in CVP was unaffected. Surprisingly, the early rise and peak in BAC in the phentolamine treated group was attenuated, but was the same as the untreated group during the final 3 hrs. These data suggest that alpha receptors are significant mediators of cardiovascular and glucoregulatory responses elicited by alcohol. Furthermore, alpha receptor blockade appears to effect the absorption and/or distribution of intragastrically administered alcohol.

• OSTI ID: 7049915
• Report Number(s): CONF-9204141-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 6:4; Conference: Federation of American Societies for Experimental Biology (FASEB) meeting, Anaheim, CA (United States), 5-9 Apr 1992; ISSN 0892-6638
• Country of Publication: United States
• Language: English

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