Genetic linkage analysis of the Ak1, Col5a1, Epb7. 2, Fpgs, Grp78, Pbx3, and Notch1 genes in the region of mouse chromosome 2 homologous to human chromosome 9q

Journal Article · Sun May 01 00:00:00 EDT 1994 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1994.1230· OSTI ID:7029793

Pilz, A ^[1]; Prohaska, R ^[2]; Peters, J ^[3]; Abbott, C ^[4]

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1. Univ. College London (United Kingdom)
2. Univ. of Vienna (Austria)
3. MRC Radiobiology Unit, Oxon (United Kingdom)
4. Univ. College London (United Kingdom) Western General Hospital, Edinburgh (United Kingdom)

The genes for adenylate kinase-1 (AK1), folyl polyglutamate synthetase (FPGS), the collagen pro[alpha]1(V) chain (COL5A1), erythrocyte protein band 7.2b (EPB72), and a proto-oncogene homeobox (PBX3) all map to the distal portion of human chromosome 9q (HSA9q) but have not previously been mapped by linkage analysis in the mouse. In this study, the authors have used two interspecific backcrosses to map the mouse homologues of each of these genes to mouse chromosome 2 (MMU2). The Ak1, Col5a1, Epb7.2, Fpgs, and Pbx3 genes were mapped with respect to the genes for Grp78, Rxra, Notch1 (the mouse homologue of TAN1), Spna2, Abl, and Hc (the mouse homologue of C5), all of which have previously been mapped by linkage analysis on MMU2 and have human homologues that map to HSA9q. Two of the reference loci for MMU2, D2Mit1 and Acra, were also mapped in the same cross to facilitate comparisons with existing maps. The consensus gene order deduced by combining data from both crosses is D2Mit1-(Dbh,Notch1)-(Col5a1,Rxra)-Spna2-Abl-(Ak1,Fpgs)-(Grp78,Pbx3)-(Epb7.2,Hc,Gsn)-Aera. These loci therefore form part of the conserved synteny between HSA9q and MMU2. 35 refs., 2 figs., 1 tab.

• OSTI ID: 7029793
• Journal Information: Genomics; (United States), Vol. 21:1; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HUMAN CHROMOSOME 9
GENETIC MAPPING
MICE
GENETICS
LIGASES
ONCOGENES
PHOSPHOTRANSFERASES
ANIMALS
BIOLOGY
CHROMOSOMES
ENZYMES
GENES
HUMAN CHROMOSOMES
MAMMALS
MAPPING
ORGANIC COMPOUNDS
PHOSPHORUS-GROUP TRANSFERASES
PROTEINS
RODENTS
TRANSFERASES
VERTEBRATES
550400* - Genetics