Spine mineral change during osteoporosis therapy
Osteoporosis therapy has been handicapped by lack of means to quantitate the process. Dual photon absorptiometry (DPA) offers accurate (4%) and precise (2%) estimation of lumbar spine mineral. The authors followed 42 osteoporotics to determine response to therapy. There were 17 patients with normal menopause (NM), 4 with surgical menopause (SM), 3 with premature menopause (PM), and 18 with idiopathic osteoporoses (10). Intervals between DPA spine mineral estimation were 16.5 +- 5.2 mo. for NM, 14.3 +- 8.4 mo. for SM, 14.0 +- 7.5 mo. for PM and 16.7 +- 5.8 mo. for 10. Observed average percent change of spine mineral under therapy for those intervals was 5.2 +- 7.9% for NM, +7.3 +- 1.7% for SM, -2.4 +- 6.3% for PM and +1.8 +- 12.3% for 10. Therapy invariably was with Ca, low dose Premarin in NM and PM, often with phosphates in IO, sometimes with thiazides, often with Vitamin D and with occasional other modalities, including NaF. The authors find DPA is a cost-effective way to measure osteopenia in the osteoporeses, document response to therapy, identify need for therapy change when there is continued bone loss under therapy, and to encourage the patient's compliance with long-term, complex therapies.
- Research Organization:
- Univ. of California School of Medicine, San Francisco, CA
- OSTI ID:
- 7029698
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BONE TISSUES
OSTEODENSITOMETRY
QUANTITATIVE CHEMICAL ANALYSIS
RELIABILITY
OSTEOPOROSIS
DIAGNOSIS
THERAPY
VERTEBRAE
ACCURACY
BIOMEDICAL RADIOGRAPHY
CHEMICAL COMPOSITION
EVALUATION
MENOPAUSE
MINERALS
PATIENTS
WOMEN
ANIMAL TISSUES
ANIMALS
BODY
CHEMICAL ANALYSIS
CONNECTIVE TISSUE
DIAGNOSTIC TECHNIQUES
DISEASES
FEMALES
MAMMALS
MAN
MEDICINE
NUCLEAR MEDICINE
ORGANS
PRIMATES
RADIOLOGY
SKELETAL DISEASES
SKELETON
TISSUES
VERTEBRATES
550602* - Medicine- External Radiation in Diagnostics- (1980-)
550900 - Pathology