In-111-labeled white blood cell uptake in noninfected closed fracture in humans: prospective study

Journal Article · Sun May 01 00:00:00 EDT 1988 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.167.2.3357961· OSTI ID:7024929

Van Nostrand, D; Abreu, S H; Callaghan, J J; Atkins, F B; Stoops, H C; Savory, C G

Since indium-111 white blood cell (In-111 WBC) scintigraphy is often used to evaluate for osteomyelitis in bone fractures, it is important to know if noninfected fractures have In-111 WBC uptake. Twenty-seven noninfected closed fracture sites in 19 patients were prospectively evaluated with technetium-99m methylene diphosphonate bone scintigraphy and In-111 WBC scintigraphy. In-111 WBC uptake was present in 41% of the 27 sites. In the 11 positive sites, the In-111 WBC uptake was 1+ (definite but minimal) in 55%, 2+ (moderate) in 36%, and 3+ (marked) in 9%. The visual intensity of the radioactive uptake on In-111 WBC scintigrams relative to that on bone scintigrams was less in 82%, equal in 9%, and greater in 9%. The visual size of the area of uptake on In-111 WBC scintigrams and bone scintigrams was smaller in 36%, equal in 55%, and greater in 9%. Factors that may help distinction of In-111 WBC uptake due to fracture alone from infection associated with fracture are discussed.

• Research Organization: Uniformed Services Univ. of Health Sciences, Washington, DC (USA)
• OSTI ID: 7024929
• Journal Information: Radiology; (United States), Vol. 167:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
INDIUM 111
UPTAKE
LEUKOCYTES
SCINTISCANNING
SKELETON
RADIONUCLIDE KINETICS
BONE FRACTURES
ISOMERIC NUCLEI
MAN
OSTEOMYELITIS
PATIENTS
TECHNETIUM 99
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INDIUM ISOTOPES
INJURIES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SKELETAL DISEASES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man
550601 - Medicine- Unsealed Radionuclides in Diagnostics