Gas exchange and intrapulmonary distribution of ventilation during continuous-flow ventilation

Journal Article · Sun May 01 00:00:00 EDT 1988 · J. Appl. Physiol.; (United States)

OSTI ID:6999942

Vettermann, J; Brusasco, V; Rehder, K

In 12 anesthetized paralyzed dogs, pulmonary gas exchange and intrapulmonary inspired gas distribution were compared between continuous-flow ventilation (CFV) and conventional mechanical ventilation (CMV). Nine dogs were studied while they were lying supine, and three dogs were studied while they were lying prone. A single-lumen catheter for tracheal insufflation and a double-lumen catheter for bilateral endobronchial insufflation (inspired O2 fraction = 0.4; inspired minute ventilation = 1.7 +/- 0.3 (SD) 1.kg-1.min-1) were evaluated. Intrapulmonary gas distribution was assessed from regional 133Xe clearances. In dogs lying supine, CO2 elimination was more efficient with endobronchial insufflation than with tracheal insufflation, but the alveolar-arterial O2 partial pressure difference was larger during CFV than during CMV, regardless of the type of insufflation. By contrast, endobronchial insufflation maintained both arterial PCO2 and alveolar-arterial O2 partial pressure difference at significantly lower levels in dogs lying prone than in dogs lying supine. In dogs lying supine, the dependent lung was preferentially ventilated during CMV but not during CFV. In dogs lying prone, gas distribution was uniform with both modes of ventilation. The alveolar-arterial O2 partial pressure difference during CFV in dogs lying supine was negatively correlated with the reduced ventilation of the dependent lung, which suggests that increased ventilation-perfusion mismatching was responsible for the increase in alveolar-arterial O2 partial pressure difference. The more efficient oxygenation during CFV in dogs lying prone suggests a more efficient matching of ventilation to perfusion, presumably because the distribution of blood flow is also nearly uniform.

• Research Organization: Mayo Clinic, Rochester, MN (USA)
• OSTI ID: 6999942
• Journal Information: J. Appl. Physiol.; (United States), Vol. 64:5
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
RESPIRATORY SYSTEM
DYNAMIC FUNCTION STUDIES
BLOOD FLOW
CARBON DIOXIDE
DOGS
OXYGEN
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RESPIRATION
TRACER TECHNIQUES
XENON 133
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
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ELEMENTS
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ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NONMETALS
NUCLEI
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
VERTEBRATES
XENON ISOTOPES
551001* - Physiological Systems- Tracer Techniques