Tumor localization in patients by radiolabeled monoclonal antibodies against colon carcinoma
A radiolabeled monoclonal antibody (MAb) that has been shown to react specifically in vitro and ex vivo to human colorectal carcinoma and to inhibit growth of human carcinomas grafted in nude mice was administered to 52 colorectal carcinoma patients and 15 patients with other types of cancer. Of 63 colorectal carcinoma tumor sites studied, 34 showed significant accumulation of antibody by external photoscanning and tomoscintigraphy, whereas none of the 20 sites of other cancer types gave positive results. One-third of the patients received F(ab')2 fragments of the MAb, which gave a slightly higher percentage (61%) of positive results than did intact MAbs (51%). A few patients scheduled for tumor resection were given injections simultaneously of /sup 131/I-labeled MAb and /sup 125/I-labeled normal immunoglobulin G. Antibody concentration in resected tumors was 3.6 to 6.3 times higher than the average antibody concentration in adjacent normal tissues (1.5, 3.4, and 9.4 as compared with normal mucosa, serosa, and fat, respectively), and the specificity indices, calculated by differential radioactivity analysis, ranged from 2.1 to 5.1. The results show the potential value and limitations of this particular MAb for tumor detection by immunoscintigraphy.
- OSTI ID:
- 6982318
- Journal Information:
- Cancer Res.; (United States), Vol. 43:11
- Country of Publication:
- United States
- Language:
- English
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CARCINOMAS
DIAGNOSIS
LARGE INTESTINE
RADIOISOTOPE SCANNING
MONOCLONAL ANTIBODIES
DIAGNOSTIC USES
LABELLING
ANTIGEN-ANTIBODY REACTIONS
IMMUNOGLOBULINS
IODINE 125
IODINE 131
LABELLED COMPOUNDS
PATIENTS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GASTROINTESTINAL TRACT
GLOBULINS
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE ISOTOPES
ISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics