( sup 14 C)iodoantipyrine and microsphere blood flow estimates in cat brain
- Univ. of Pennsylvania, Philadelphia (USA)
A comparison of local cerebral blood flow estimates with the microsphere and the 4-(N-methyl-{sup 14}C)iodoantipyrine (({sup 14}C)IAP) techniques has been performed in cats. Good correlation of ({sup 14}C)IAP with microsphere flow estimates in the gray matter was found. In the white matter, however, ({sup 14}C)IAP flow estimates were consistently lower than microsphere flow estimates. Error analysis of both techniques and comparison with previous studies suggest that peculiarities of white matter arterial vasculature with preferential microsphere accumulation may lead to this discrepancy. Microspheres did not interfere with flow as shown by the normal appearance of subsequent ({sup 14}C)IAP autoradiograms. The number of microspheres seen on autoradiograms was used for an estimate of microvessels blocked by spheres and found to be negligible. The study also demonstrates that ({sup 14}C)IAP is not diffusion limited up to the observed flow values of 2 ml {center dot} g{sup {minus}1} {center dot} min{sup {minus}1}. Both techniques might be used together for a combination of their respective advantages, which are temporal and spatial resolution for microsphere and ({sup 14}C)IAP, respectively.
- OSTI ID:
- 6974699
- Journal Information:
- American Journal of Physiology; (USA), Vol. 253:5; ISSN 0002-9513
- Country of Publication:
- United States
- Language:
- English
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551001* - Physiological Systems- Tracer Techniques