Uncertainty in exposure and health-risk assessment: An integrated approach
The goal of this paper is to consider a strategy for evaluating and reducing sources of uncertainty in predictive exposure and health-risk assessments. We focus on the volatile organic chemical tetrachloroethylene (PCE) in California water systems derived from ground water. We divide our analysis into five steps. First, we consider the magnitude and variability of PCE concentrations available in large public water supplies in California. Second, we characterize pathway exposure factors (PEFs) for ground water exposures and estimate uncertainty for each PEF. Third, we consider models describing uptake and metabolism to estimate the relation between exposure and metabolized dose. Fourth, we consider the carcinogenic potency of the metabolized PCE dose. Finally, we combine the results to estimate the overall magnitude and uncertainty of individual risk within the exposed population. 19 refs., 13 figs., 1 tab.
- Research Organization:
- Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- DOE/DP; USEPA
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 6949486
- Report Number(s):
- UCRL-102225; CONF-900676-9; ON: DE90012988
- Resource Relation:
- Conference: 83. annual meeting and exhibition of the Air and Waste Management Association, Pittsburgh, PA (USA), 24-29 Jun 1990
- Country of Publication:
- United States
- Language:
- English
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Uncertainties in health-risk assessment: an integrated case study based on tetrachloroethylene in California groundwater
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ENVIRONMENTAL EXPOSURE PATHWAY
BIOLOGICAL MODELS
GROUND WATER
CONTAMINATION
HUMAN POPULATIONS
ENVIRONMENTAL EXPOSURE
ORGANIC CHLORINE COMPOUNDS
HEALTH HAZARDS
WATER SUPPLY
CALIFORNIA
POLLUTANTS
PUBLIC UTILITIES
RISK ASSESSMENT
SOURCE TERMS
SPATIAL DOSE DISTRIBUTIONS
TEMPORAL DOSE DISTRIBUTIONS
TOXICITY
VOLATILE MATTER
FEDERAL REGION IX
HAZARDS
HYDROGEN COMPOUNDS
MATTER
NORTH AMERICA
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OXYGEN COMPOUNDS
POPULATIONS
RADIATION DOSE DISTRIBUTIONS
USA
WATER
540320* - Environment
Aquatic- Chemicals Monitoring & Transport- (1990-)
560161 - Radionuclide Effects
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& Toxicology- Man