Quantitative comparison of the regional distributions of inhaled Tc-99m DTPA aerosol and Kr-81m Gas in coal miners' lungs
The authors compared the regional distribution of deposited Tc-99m DTPA aerosol (D) with that of Kr-81m (K) in the upright lungs of 22 coal miners with non-embolic pulmonary disease. Pixel-by-pixel distribution of K and D, as well as K/D ratios, were determined by computer analysis in each lung and presented as digitized posterior images. The lungs were also divided into 6.5-mm horizontal slices between apex and base. Values of the mean K and D counts and K/D ratio were plotted as functions of slice position. Good peripheral lung penetration was obtained for all subjects, while hot spots in the central airways were found in only one lung of a subject who smoked and had airway obstruction. Assessment of ventilation by visual evaluation of the respective images was comparable for both K and D. However, computer analysis showed that D was preferentially deposited in the basal regions of 38/44 lungs. K was preferentially distributed in the apical regions of 28/44 lungs. Increased bilateral D deposition in the basal regions was accompanied by a reduction in the apical regions of 10 subjects and in one lung of another 7 subjects. No relationship was found between aerosol deposition and ventilation/perfusion or pulmonary function measurements. In previous studies they have reported rapid aerosol clearance in coal miners. Although accurate clinical information has been obtained with D in patients with suspected pulmonary embolism, the effect of gravity on the deposition of D may limit its usefulness when quantitative information is required to evaluate subtle changes in ventilation in non-embolic pulmonary patients and for basic studies of ventilation and perfusion.
- Research Organization:
- Brookhaven National Lab., Upton, NY
- OSTI ID:
- 6940353
- Report Number(s):
- CONF-850611-; TRN: 87-015128
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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AEROSOL MONITORING
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550601* - Medicine- Unsealed Radionuclides in Diagnostics