Absence of bile acid malabsorption as a late effect of pelvic irradiation
The pathophysiology of chronic radiation-induced diarrhea was evaluated in 28 patients who had undergone pelvic irradiation for gynecologic neoplasms 2 to 7 years previously. Twenty-seven patients undergoing radiotherapy with techniques that did not require abdominal or pelvic irradiation served as controls. The glycine conjugates of cholic acid (GC) were measured in serum by radioimmunoassay. Fasting and 2 hr. pp GC levels for the pelvic irradiated patients were 11.0 +/- 11.1 (mean +/- SD) and 24.8 +/- 17.3 micrograms/dl. Fasting and 2 hr. pp GC levels for controls were 12.6 +/- 7.4 and 28.0 +/- 14.7. There were no significant differences in the post-prandial increases in serum GC between pelvic irradiated patients and controls (p = .23, Type II error probability = .13). There was also no significant difference in the 2 hr. pp and fasting GC ratio (p = .39). There was significant difference between the stool frequency (p less than .01) and the prevalence of diarrhea (p less than .02) between pelvic irradiated patients and controls. The data suggest that bile acid malabsorption due to ileal dysfunction is not an inevitable late complication of pelvic irradiation and is not the major determinant in the pathophysiology of chronic radiation-induced diarrhea.
- Research Organization:
- Pennsylvania State Univ., Hershey
- OSTI ID:
- 6934140
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
CHOLIC ACID
INTESTINAL ABSORPTION
RADIOIMMUNOASSAY
DIARRHEA
RADIOINDUCTION
RADIOTHERAPY
SIDE EFFECTS
CHRONIC IRRADIATION
NEOPLASMS
PATIENTS
PELVIS
UROGENITAL SYSTEM DISEASES
ABSORPTION
BILE ACIDS
BODY
BODY AREAS
CARBOXYLIC ACIDS
CHRONIC EXPOSURE
DISEASES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
IRRADIATION
ISOTOPE APPLICATIONS
MEDICINE
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOASSAY
RADIOIMMUNOLOGY
RADIOLOGY
STEROIDS
STEROLS
SYMPTOMS
THERAPY
TRACER TECHNIQUES
UPTAKE
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)