Study of cerebral ischemic reversibility: Part II. Preliminary preoperative results of fluoromethane positron emission tomographic determination of perfusion reserve in patients with carotid TIA and stroke
Symmetries and asymmetries in regional cerebral blood flow (rCBF) determinations are reported in eleven patients with symptomatic carotid artery occlusive disease. Flourine-18-fluoromethane rCBF values are obtained by means of a noninvasive positron emission tomographic (PET) technique during room air (RA) and following induced hypercapnia (CO/sub 2/). Areas of abnormal CO/sub 2/ reactivity predict both the hemodynamic significance of the vascular lesion in question and the areas most vulnerable for ischemic infarction. This data is intended to be preliminary in nature; future expansions of this data base will be made to include rCBF/CO/sub 2/ estimations, rCBF/glucose metabolism determinations, and rCBF/reserve evaluations over time and following brain-specific therapies. Once established, the potential viability and reversibility of these ischemic, uninfarcted or minimally infarcted areas can then be reestablished over time, thus providing a quantitative measure of the natural history of flow/metabolic coupling or uncoupling.
- Research Organization:
- William S. Middleton Veterans Administration Hospital, Madison, WI (USA)
- OSTI ID:
- 6908605
- Journal Information:
- Am. J. Physiol. Imag.; (United States), Vol. 1:2
- Country of Publication:
- United States
- Language:
- English
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BRAIN
BLOOD FLOW
POSITRON COMPUTED TOMOGRAPHY
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FLUORINE 18
PATIENTS
PERFUSED ORGANS
TRACER TECHNIQUES
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
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CARBOHYDRATES
CARBON COMPOUNDS
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
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EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
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LIGHT NUCLEI
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
SACCHARIDES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics