Effects of captopril on cerebral blood flow in normotensive and hypertensive rats
Cerebrovascular effects of the angiotensin converting enzyme inhibitor captopril were examined in normotensive and hypertensive rats. Cerebral blood flow was measured with the intracarotid /sup 133/xenon injection method in halothane-anesthetized animals. The blood-brain barrier permeability of captopril (determined with an integral-uptake method) was negligible, the permeability-surface area product in most brain regions being 1 X 10(-5) cm3/g per second, that is, three to four times lower than that of sodium ion. When administered into the cerebral ventricles to bypass the blood-brain barrier, captopril had no effect on cerebral blood flow: furthermore, cerebral blood flow autoregulation (studied by raising and lowering blood pressure) was identical to that in controls. In contrast, when given intravenously, captopril had a marked effect on cerebral blood flow autoregulation--both the lower and upper limits of autoregulation being shifted to a lower pressure (by about 20 to 30 and 50 to 60 mm Hg, respectively), and the autoregulatory range was shortened by about 40 mm Hg. This effect may be ascribed to inhibition of converting enzyme in the cerebral blood vessels rather than within the brain.
- Research Organization:
- Department of Psychiatry, Rigshospitalet, Copenhagen, Denmark
- OSTI ID:
- 6885297
- Journal Information:
- Am. J. Med.; (United States), Vol. 76:5B
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BRAIN
BLOOD FLOW
ENZYME INHIBITORS
BIOLOGICAL EFFECTS
BLOOD-BRAIN BARRIER
HYPERTENSION
INHALATION
PERMEABILITY
RATS
TRACER TECHNIQUES
XENON 133
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
XENON ISOTOPES
551001* - Physiological Systems- Tracer Techniques