Toxic Hazards Research Unit annual report: 1987. Report No. 24, October 1986-October 1987

Technical Report · Tue Mar 01 00:00:00 EST 1988

OSTI ID:6878481

Houston, W E; Kutzman, R S

The report was prepared as a review of the activities of the Toxic Hazards Research Unit for the period of October 1986 through September 1987. Research activities focused on toxicity evaluations of aerospace and naval chemicals and materials to include hydraulic fluids, lubricating oils, ground-water contaminants, chemical-defense simulants, and binary-agent components. Physiologically based pharmacokinetic/pharmacodynamic modeling was developed and provides methods for simulating the toxicological effects of selected chemicals, including models for chemical carcinogenesis. The completion and utilization of the General Toxicology Laboratory within the THRU has resulted in the completion of an increased number of acute and repeated treatment studies, and additional subchronic studies are planned. The objectives of this research program are to identify and characterize the toxic effects of chemicals, compounds, and materials that are of operational interest and concern to the Air Force and Navy. This coordinated USAF-USN program generates scientific information from which simulation and predictive models, experimental design,and risk assessment criteria can be developed.

• Research Organization: Northrop Services, Inc./Environmental Sciences, Dayton, OH (USA)
• OSTI ID: 6878481
• Report Number(s): AD-A-198097/8/XAB
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHEMICAL WARFARE
TOXIC MATERIALS
HAZARDOUS MATERIALS
HEALTH HAZARDS
BERYLLIUM OXIDES
CARCINOGENESIS
GROUND WATER
HYDRAULIC FLUIDS
LUBRICATING OILS
PROGRESS REPORT
SIMULATION
TOXICITY
WATER POLLUTION
ALKALINE EARTH METAL COMPOUNDS
BERYLLIUM COMPOUNDS
CHALCOGENIDES
DOCUMENT TYPES
FLUIDS
HAZARDS
HYDROGEN COMPOUNDS
LUBRICANTS
MATERIALS
OILS
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
PETROLEUM PRODUCTS
POLLUTION
WARFARE
WATER
WORKING FLUIDS
550900* - Pathology