Hematoporphyrin derivative uptake and photodynamic therapy in pancreatic carcinoma
Little information is currently available concerning the uptake of porphyrins by pancreatic tumors, or the effect of photodynamic therapy (PDT) on pancreatic cancer. In Syrian golden hamsters (n = 33), the organ distribution of /sup 125/I-labeled dihematoporphyrin ether (DHE) was studied in a pancreatic cancer model. In the same animal model the effect of PDT was studied using a gold vapor laser for energy delivery 3 hr after the injection of DHE (n = 7). DHE was 2.4 times more concentrated in the pancreatic tumor than in the nontumorous pancreas at 3 hr. Simultaneously there was a considerable accumulation of DHE in the surrounding gastrointestinal tract, causing perforation of the duodenum and jejunum with resultant death in four (57%) animals after PDT. Photodynamic therapy caused extensive tumor necrosis without any obvious effect on the nontumor-bearing pancreas. Damage to the surrounding tissue in the hamster indicates that precautions should be taken if PDT is to be used clinically in pancreatic cancer. Intratumoral injection of DHE may give higher drug concentrations with greater specificity for tumor treatment.
- Research Organization:
- Univ. of Cincinnati Medical Center, OH (USA)
- OSTI ID:
- 6856932
- Journal Information:
- J. Surg. Oncol.; (United States), Vol. 38:1
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HEMATOPORPHYRINS
TISSUE DISTRIBUTION
UPTAKE
LASER RADIATION
BIOLOGICAL EFFECTS
PANCREAS
CARCINOMAS
BIOLOGICAL MODELS
HAMSTERS
LASERS
ANIMALS
BODY
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MAMMALS
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PORPHYRINS
RADIATIONS
RODENTS
VERTEBRATES
550901* - Pathology- Tracer Techniques
560400 - Other Environmental Pollutant Effects