Value of quantitative exercise thallium-201 scintigraphy for predicting restenosis after successful percutaneous transluminal coronary angioplasty
The authors sought to determine the ability of quantitative exercise thallium-201 (Tl-201) scintigraphy (ex-T1) to predict early restenosis following angiographically successful percutaneous transluminal coronary angioplasty (PTCA). Ex-Tl was performed 2.6 +- 2.1 weeks (range 0-9) weeks following PTCA in 55 patients; exercise was symptom limited in 54 and heart rate limited in 1. During a mean followup period of 8.5 months (range 3-24), restenosis occurred in 11 patients (20%) and myocardial infarction in 1 (1.7%); restenosis occurred 2.2 +- 1.1 months following the procedure. Of this group, only one patient (1/12; 8%) demonstrated unequivocal redistribution in the scan region of the dilated vessel; other patterns included two patients with delayed washout, three with persistent defects, and six with normal Tl-201 uptake and washout. Eight patients (8/55; 15%) demonstrated redistribution in the scan region of the dilated vessel following PTCA. Of these, five had angiographic evidence of incomplete revascularization with stenosis (greater than or equal to 50%) involving the distal dilated vessel or side branches. The authors conclude that: 1) Normalization of myocardial perfusion as assessed by ex-Tl following PTCA does not preclude early restenosis; and 2) Evidence of residual ischemia by ex-Tl in the scan region of the dilated vessel following PTCA is frequently associated with angiographic evidence of incomplete revascularization.
- Research Organization:
- Univ. of Virginia Medical Center, Charlottesville, VA
- OSTI ID:
- 6854966
- Report Number(s):
- CONF-850611-; TRN: 87-010754
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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