Local stem cell depletion model for radiation myelitis

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(88)90404-X· OSTI ID:6840208

Yaes, R J; Kalend, A

We propose a model for normal tissue damage based on the assumption that adult mammalian stem cells have limited mobility and, consequently, for each organ, there is a maximum volume (the critical volume, Vc), that can be repopulated and repaired by a single surviving stem cell. This concept is applied to a simple, 1-dimensional model of the spinal cord, where the critical volume is a slice of thickness, t, assumed to be small compared to lengths of spinal cord usually irradiated clinically. The probability of myelitis is explicitly obtained as a function of the dose, dose per fraction, length of cord irradiated, slice thickness, number of stem cells per slice and parameters alpha and beta of the stem cell survival curve. The complication probability is expressed as a triple negative exponential function of dose analogous to the double negative exponential function for tumor control, resulting in a steep dose-response curve with short tails in both the high dose and low dose regions. We show that the model predictions are compatible with the experimental data for radiation myelitis in the rat. We discuss how this concept can be applied to other organs such as skin and to organs composed of structurally and functionally distinct subunits, such as the kidney.

• Research Organization: Univ. of Kentucky Medical Center, Lexington (USA)
• OSTI ID: 6840208
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 14:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MYELITIS
RADIOINDUCTION
RADIATION INJURIES
MATHEMATICAL MODELS
BIOLOGICAL MODELS
DOSE-RESPONSE RELATIONSHIPS
PROBABILITY
RADIATION DOSES
RADIOTHERAPY
RATS
SKIN
SPINAL CORD
STEM CELLS
SURVIVAL CURVES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CENTRAL NERVOUS SYSTEM
DISEASES
DOSES
INJURIES
MAMMALS
MEDICINE
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
RODENTS
SOMATIC CELLS
THERAPY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals