Radionuclide measurement of colon transit in man
Scintigraphy was used to measure colonic transit in 10 normal subjects. Following 3 days of a fixed diet, an oral catheter was advanced to the cecum under fluoroscopic control and 50 ..mu..Ci of In-111 DTPA in 8 ml of electrolyte was injected as a bolus. Movement of the cecal instrillate was monitored with a large field of view camera and computer for 48 hours. Initial cecal-ascending colon emptying was exponential. Ninety percent of the bolus had emptied at 194 +- 26 min. Dividing the colon into seven regions: cecum (1), hepatic flexure (2), transverse colon (3), splentic flexure (4), descending colon (5), signoid colon and rectum (6), excreted feces (7) the mean percent of the instillate with time at each location was calculated. Antegrade and retrograde movement of the colonic contents was documented. The results show that emptying of the proximal colon is exponential and the distal colon is linear. The authors conclude that colonic scintigraphy can be used to quantify regional colonic motility.
- Research Organization:
- Temple Univ. Health Sciences Center, Philadelphia, PA
- OSTI ID:
- 6794209
- Report Number(s):
- CONF-850611-; TRN: 87-010751
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
DIGESTION
MONITORING
LARGE INTESTINE
DYNAMIC FUNCTION STUDIES
CAMERAS
COMPUTERS
FLUOROSCOPY
PHYSIOLOGY
RECTUM
TISSUE DISTRIBUTION
UPTAKE
BIOMEDICAL RADIOGRAPHY
BODY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
GASTROINTESTINAL TRACT
INTESTINES
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques