Glucose transport and utilization in the human brain: model using carbon-11 methylglucose and positron emission tomography

Journal Article · Mon Dec 01 00:00:00 EST 1986 · J. Nucl. Med.; (United States)

OSTI ID:6782260

Feinendegen, L E; Herzog, H; Wieler, H; Patton, D D; Schmid, A

3-0-(11C)-Methyl-D-glucose (CMG) is specifically suited for measuring carrier facilitated glucose (G) transport; it enters the free G pool in tissue from where it is not utilized for metabolism in contrast to G, but is transported back into circulation. The ratio of carrier affinity for G and CMG was reported to be 1.11. By simultaneously measuring CMG concentration in plasma and in cerebral cortex in vivo with positron tomography at 1-min intervals for 40 min, two time-activity curves are obtained, as reported previously, which together with the G concentration in plasma yield the in vivo rate constants of G transport across the blood-brain barrier and the rate of G inflow; a repeat measurement at a different G concentration in plasma gives the in vivo Michaelis-Menten constant KM and the maximal rate of transport VMAX. The present paper summarizes and extends this approach to analyzing the free G pool in tissue, the rate of G return to circulation, and the rate of G exit into metabolism with its corresponding rate constants. The data from six volunteers agreed with results reported for the individual biochemical parameters in primate brains.

• Research Organization: Institute of Medicine, Nuclear Research Center, Juelich, Germany, F.R.
• OSTI ID: 6782260
• Journal Information: J. Nucl. Med.; (United States), Vol. 12
• Country of Publication: United States
• Language: English

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CARBON 11
MAN
MATHEMATICAL MODELS
ALDEHYDES
ANIMALS
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HEXOSES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRIMATES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics