Measurement in vivo of dopamine receptor density II: Effect of d-amphetamine on spiroperidol binding
In the authors continuing studies to measure dopamine (DA) receptors in vivo using the DA antagonist bromospiroperidol (BrSP) and positron emission tomography (PET). The authors have examined the effect of d-amphetamine (d-AMP) on BrSP distribution in primate brain. Using the University of Chicago PETT VI scanner, /sup 76/Br-BrSP was found to localize in the caudate and putamen of anesthetized rhesus monkeys. The maximum level of this drug in these regions was reached at 100 minutes post-injection and remained constant for the next 200 minutes. Levels in the cerebellum, on the other hand, decline steadily after an hour post-injection. This is consistent with the presence of high level of DA receptors in the basal ganglia and low levels in the cerebellum. Preliminary studies showed that the administration of d-AMP (0.5 mg/kg i.v.) resulted in a small but statistically significant decrease in caudate /sup 76/Br-BrSP levels. Since d-AMP is known to release DA in the caudate, these findings are consistent with the competition of released DA for BrSP binding at caudate DA binding sites.
- Research Organization:
- The Univ. of Chicago, Chicago, IL 60637
- OSTI ID:
- 6779156
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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POSITRON COMPUTED TOMOGRAPHY
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IN VIVO
INJECTION
AMINES
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ANIMALS
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AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
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EMISSION COMPUTED TOMOGRAPHY
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INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
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MAMMALS
MEMBRANE PROTEINS
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NUCLEI
ODD-ODD NUCLEI
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550602* - Medicine- External Radiation in Diagnostics- (1980-)
550601 - Medicine- Unsealed Radionuclides in Diagnostics