A new technique for quantification of platelet thrombosis on bovine pericardial valve prostheses (Ionescu-Shiley) in calves with indium-111 labeled platelets
Platelet thrombosis on components of tissue valve prosthesis explanted from Holstein calves was quantified with In-111-labeled autologous platelets. Twenty-eight calves were implanted with 25 mm bovine pericardial valve prostheses in mitral annulus and killed 1, 14, 30 and 90 days post-implantation. Twenty-four hours before killing 350-450 ..mu..Ci of autologous In-111 platelets were administered intravenously. Components of the explanted valve were imaged with a gamma camera. Mean (+- SD) value of platelet deposition (PlX10/sup 5//mm/sup 2/) on four sections of each leaflet (free edge: FE, central zone: CZ, flexion zone: FZ, attachment zone: AZ) was calculated from platelet count, radioactivity in blood, leaflet sections and area of leaflet sections. With fibrous ingrowth in sewing ring the tissue valve becomes less thrombogenic at 30 days post-implantation; with increase in calcification platelet thrombosis also increases in central zone of leaflet at 30 and 90 days.
- Research Organization:
- Mayo Clinic and Foundation, Rochester, MN
- OSTI ID:
- 6759979
- Report Number(s):
- CONF-850611-; TRN: 87-010718
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD PLATELETS
LABELLING
EMBOLI
DETECTION
HEART
PROSTHESES
THROMBOSIS
PERICARDIUM
BIOCHEMISTRY
BLOOD COAGULATION
CAT SCANNING
COWS
GAMMA CAMERAS
GRAFT-HOST REACTION
INDIUM 111
PATHOLOGICAL CHANGES
SCINTISCANNING
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CAMERAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CATTLE
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MEDICAL SUPPLIES
MEMBRANES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RUMINANTS
SEROUS MEMBRANES
TOMOGRAPHY
VASCULAR DISEASES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics