Adenocarcinoma of the lung: ten years' experience in Southern Alberta Cancer Center
During the period from 1968 to 1977, 1223 patients with carcinoma of the lung were registered at the Southern Alberta Cancer Center, of whom 121 (10%) had adenocarcinoma of the lung. A detailed retrospective analysis was undertaken to determine prognostic factors and the causes of treatment failure. The median age of the patients was 60 years. Curative surgical removal was accomplished in 63 patients; in 19 patients biopsy or palliative resection only was possible at the time of thoracotomy. Cobalt teletherapy was given to the primary site and mediastinum in 50 patients, with tumor doses ranging from 3000 rad in 2 weeks to 5000 rad in 5 weeks. Chemotherapy was given to 24 patients, either single agent or combination, using Cyclophosphamide, Vincristine, Methotrexate and 5 Fluoruracil. The 2 year actuarial survival rate was 59% for Stage 1 (standard error 0.13), 17% for Stage 2 (standard error 0.11) and 6% for Stage 111 (standard error 0.03). The important prognostic factors were stage of tumor, size of tumor, nodal status, presence of distant metastases, differentiation of tumor, involvement of the resection margin, performance status, and the level of hemoglobin at the time of diagnosis. Sex, age of the patient, and radiation dose did not affect the prognosis. Most of the recurrences and deaths occurred within 2 years of diagnosis (45/47). Among the 47 recurrences, 10 patients had only brain metastases with primary site control, 10 patients had a first recurrence in the primary site which had not been irradiated, 5 had a recurrence at a nonirradiated regional lymphatic site, 4 had a recurrence at the irradiated primary site, 8 had a recurrence at other sites, and 10 had multiple metastases at the time of treatment failure. The role of prophylactic brain radiation may have to be found with well controlled clinical trials.
- Research Organization:
- Southern Alberta Cancer Center, Calgary
- OSTI ID:
- 6759182
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 6:7
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BRAIN
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
LUNGS
COBALT 60
ENDOXAN
FLUOROURACILS
HEMOGLOBIN
MEDIASTINUM
METASTASES
METHOTREXATE
ONCOVIN
PATIENTS
RADIATION DOSES
RADIOTHERAPY
SURVIVAL TIME
ALKALOIDS
ALKYLATING AGENTS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHEST
COBALT ISOTOPES
DISEASES
DOSES
DRUGS
GLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PORPHYRINS
PROTEINS
PYRIMIDINES
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RESPIRATORY SYSTEM
THERAPY
URACILS
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man