Human sperm chromosomes. Long-term effect of cancer treatment

Journal Article · Fri Jun 01 00:00:00 EDT 1990 · Cancer Genetics and Cytogenetics; (USA)

OSTI ID:6748895

Genesca, A; Caballin, M R; Miro, R; Benet, J; Bonfill, X; Egozcue, J ^[1]

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1. Universitat Autonoma de Barcelona (Spain)

The long-term cytogenetic effect of radio- or chemotherapy or both on male germ cells was evaluated by study of the chromosomal abnormalities in spermatozoa of four men treated for cancer 5-18 years earlier. The cytogenetic analysis of 422 sperm metaphases showed no differences in the aneuploidy rate. The incidence of structural chromosome aberrations was 14.0%, however, which is much higher than in controls. Thus, the high incidence of structurally aberrant spermatozoa observed in our long-term study indicates that antitumoral treatments affect stem-cell spermatogonia and that aberrant cells can survive germinal selection and produce abnormal spermatozoa.

• OSTI ID: 6748895
• Journal Information: Cancer Genetics and Cytogenetics; (USA), Vol. 46:2; ISSN 0165-4608
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHROMOSOMAL ABERRATIONS
RADIOINDUCTION
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SIDE EFFECTS
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