Radiation-induced inhibition of compensatory renal growth in the weanling mouse kidney. [X rays]

Conference · Tue Aug 01 00:00:00 EDT 1978 · Radiology; (United States)

OSTI ID:6736702

Donaldson, S S; Moskowitz, P S; Canty, E L; Efron, B

Weanling mice were given 500, 1,000, 1,500, or 2,000 rads single-fraction renal irradiation immediately following unilateral nephrectomy and sacrificed 3 days or 3, 6, 12, or 24 weeks later. Inhibition of compensatory renal growth was related to both radiation dose and time following treatment; it was transient following 500 and 1,000 rads but persisted following 1,500 and 2,000 rads. Renal growth was inhibited more than body growth. These studies indicate that the weaning mouse kidney is more sensitive to radiation-induced inhibition of compensatory renal growth than adult mice or other rodents.

• Research Organization: Stanford Univ., CA
• OSTI ID: 6736702
• Journal Information: Radiology; (United States), Vol. 128:2; Conference: 63. scientific assembly and annual meeting of the Radiological Society of North America, Chicago, IL, USA, 27 Nov 1977
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
KIDNEYS
RADIOSENSITIVITY
AGE DEPENDENCE
AGE GROUPS
DOSE-RESPONSE RELATIONSHIPS
LOCAL IRRADIATION
MICE
NEPHRECTOMY
X RADIATION
ANIMALS
BODY
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MEDICINE
ORGANS
RADIATIONS
RODENTS
SURGERY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals