Effect of anticholinesterase agents on airway epithelial function. Annual report, 15 July 1985-14 July 1986
Irreversible anticholinesterase compounds have potential serious deleterious health effects when employed as chemical warfare agents. Intoxication with these agents will cause an accumulation of acetylcholine at nerve muscle and nerve gland junctions. Because tracheal submucosal glands have rich cholinergic innervation, we hypothesized that exposure to anticholinesterase agents, such as soman, would stimulate glandular secretion. This would cause pathological changes in the important lung defense mechanism of mucociliary clearance. Despite the potential importance of anticholinesterases to lung function, little information was available concerning the effects of these agents on mucociliary transport. The initial technical objectives of this proposal were to modify a technique and to utilize it to study mucociliary transport in the ferret in vivo. Utilizing this technique, we have begun to define baseline mucociliary transport rates in anesthetized ferrets. Furthermore, studies have been under way to determine the effect of atropine on this transport rate. This report delineates the progress thus far. It was shown that mucociliary transport remains relatively constant over a 5 1/2-hour time period, with a mean transport rate between 16.7 and 20.7 mm/min. Initial studies utilizing atropine indicate that there is a decrease in transport rate following the administration of atropine, which reaches a nadir at about 2 hours following administration of atropine.
- Research Organization:
- Rochester Univ., NY (USA)
- OSTI ID:
- 6731909
- Report Number(s):
- AD-A-195733/1/XAB
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHEMICAL WARFARE AGENTS
BIOLOGICAL EFFECTS
RESPIRATORY SYSTEM DISEASES
ACETYLCHOLINE
ATROPINE
CHOLINESTERASE
FUNCTIONS
IRREVERSIBLE PROCESSES
NERVES
PATHOLOGY
PROGRESS REPORT
SECRETION
TOXICITY
TRANSPORT
ALKALOIDS
AMINES
AMMONIUM COMPOUNDS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARBOXYLESTERASES
DISEASES
DOCUMENT TYPES
DRUGS
ENZYMES
ESTERASES
ESTERS
HYDROLASES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
PARASYMPATHOLYTICS
PARASYMPATHOMIMETICS
QUATERNARY COMPOUNDS
WEAPONS
550900* - Pathology
560300 - Chemicals Metabolism & Toxicology