Whole-body retention of /sup 65/Zn during pregnancy and lactation, and its secretion into milk in mice
The relationship between the maternal whole-body retention of /sup 65/Zn during pregnancy and lactation was studied in mice. Mice administered /sup 65/Zn late in gestation had extremely high retention before parturition which was followed by an abrupt decrease after parturition. The magnitude of the abrupt decrease of maternal body burden becomes smaller with an increase in the interval between administration of isotope and parturition, i.e., the greater the interval between administration and parturition, the smaller the fetal uptake of /sup 65/Zn during intrauterine life. The amount of /sup 65/Zn secreted into milk was estimated from the pup's body burden during the nursing period. When /sup 65/Zn was administered 5 days after parturition to dams nursing eight pups each, the maximum body burden of the litter reached 64% of the initial dose 10 days after injection. In mouse dams, the secretion of /sup 65/Zn in milk is an important elimination pathway in addition to excretion in feces.
- Research Organization:
- Iwate Univ., Japan
- OSTI ID:
- 6716766
- Journal Information:
- Radiat. Res.; (United States), Vol. 75:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LACTATION
PREGNANCY
ZINC 65
RETENTION
SECRETION
BIOLOGICAL EFFECTS
MICE
MILK
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FOOD
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
NUCLEI
RADIOISOTOPES
RODENTS
VERTEBRATES
ZINC ISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)