Effect of blood transfusions on canine renal allograft survival

Journal Article · Thu Apr 01 00:00:00 EST 1982 · Transplantation; (United States)

DOI:https://doi.org/10.1097/00007890-198204000-00011· OSTI ID:6715961

Van Der Linden, C J; Buurman, W A; Vegt, P A; Greep, J M; Jeekel, J

In this study significantly prolonged canine renal allograft survival has been demonstrated after transfusion of 100 ml of third-party whole blood given peroperatively. Peroperative transfusions of third-party leukocyte-free blood or pure lymphocyte cell suspensions did not influence graft survival. Futhermore, no improvement in graft survival has been found after a peroperative transfuson of irradiated whole blood (2500 rad). These data suggest that delayed graft rejection after blood transfusions can only be expected after the administration of whole blood. The role of competent lymphocytes in whole blood is questionable, since a transfusion of irradiated whole blood in combination with nonirradiated lymphocytes did not lead to prolonged graft survival. Immunosuppression of the recipient directly after transfusion seems to be essential to induce the beneficial effect of blood transfusions. This has been demonstrated for a transfusion of whole blood 14 days before transplantation. A single transfusion of 100 ml of whole blood 14 days before transplantation could effectively prolong graft survival if immunosuppression with azathioprine and prednisone was started on the day of transfusion. No improvement in graft survival has been found with such a transfusion if preoperative immunosuppression has been omitted.

• Research Organization: State Univ. of Limburg, Netherlands
• OSTI ID: 6715961
• Journal Information: Transplantation; (United States), Vol. 33:4
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD
IMMUNOSUPPRESSION
GRAFTS
IMMUNOLOGY
TRANSFUSIONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DOGS
KIDNEYS
LYMPHOCYTES
PREDNISONE
ADRENAL HORMONES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
CORTICOSTEROIDS
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
KETONES
LEUKOCYTES
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
PREGNANES
RADIATION EFFECTS
SOMATIC CELLS
STEROID HORMONES
STEROIDS
THERAPY
TRANSPLANTS
VERTEBRATES
551000* - Physiological Systems
560152 - Radiation Effects on Animals- Animals