Magnetic studies of radiation damage. Final report, May 1965 to October 1982
The objective of this research was to identify the molecular products produced by ionizing radiation in compounds of biological interest. The approach used was principally electron spin resonance (ESR) spectroscopy and electron-nuclear double resonance (ENDOR) spectroscopy studies of primary free radical products. For the most part, studies were conducted on single crystals. Irradiations were often at low temperature (4.2/sup 0/K) in order to stabilize primary products. The important results to date have been the identification of primary oxidation and reduction products that are produced in nucleic acid constituents. The significance of these results lies in the fact that the processes of radiation-induced carcinogenesis, mutagenesis and probably cell death are intimately related to damage to DNA.
- Research Organization:
- Roswell Park Memorial Inst., Buffalo, NY (USA)
- DOE Contract Number:
- AC02-76EV03212
- OSTI ID:
- 6715557
- Report Number(s):
- DOE/EV/03212-48; ON: DE83002792
- Country of Publication:
- United States
- Language:
- English
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CARCINOGENESIS
RADIOINDUCTION
NUCLEIC ACIDS
RADIATION INJURIES
RADIOLYSIS
ANIMAL CELLS
BIOLOGICAL MATERIALS
ELECTRON BEAMS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
DECOMPOSITION
INJURIES
LEPTON BEAMS
MATERIALS
ORGANIC COMPOUNDS
PARTICLE BEAMS
PATHOGENESIS
RADIATION CHEMISTRY
RADIATION EFFECTS
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Cells
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