Newly synthesized hypoxia-mediated drugs as radiosensitizers and cytotoxic agents
- Columbia Univ., New York, NY
Chinese hamster cells in culture were used to compare the radiosensitizing efficiency and cytotoxicity of misonidazole with several 2, 4 and 5 substituted nitroimidazoles. The two substituted compounds (SR 2508 and SR 2555) are similar to misonidazole in radiosensitizing effectivenss, but are significantly less toxic to hypoxic cells. This reduced cytotoxicity may result from either slower drug penetration or slower removal of non-protein sulfhydryl compounds (NPSH). The compound MJL-1-191-VII* (a 4-nitroimidazole) is a much more effective radiosensitizer than would be predicted from its electron affinity. It appears to sensitize by two mechanisms, the first resulting from its electron affinity and the second a consequence of its rapid removal of endogeneous cellular NPSH; which are naturally occurring radioprotective substances.
- OSTI ID:
- 6712619
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
IMIDAZOLES
AFFINITY
RADIOSENSITIVITY EFFECTS
MISONIDAZOLE
ANOXIA
CELL CULTURES
COMPARATIVE EVALUATIONS
FIBROBLASTS
HAMSTERS
NITRO COMPOUNDS
OXYGEN
RADIOSENSITIZERS
THIOLS
TOXICITY
ANIMAL CELLS
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
CONNECTIVE TISSUE CELLS
DRUGS
ELEMENTS
HETEROCYCLIC COMPOUNDS
MAMMALS
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RODENTS
SOMATIC CELLS
VERTEBRATES
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
560121 - Radiation Effects on Cells- External Source- (-1987)