Radioaerosol clearance to monitor effects of ozone on lung permeability
The Tc-99m DTPA aerosol clearance procedure was used to investigate the effects of low level ozone inhalation on lung permeability. Total and regional lung clearance was determined by scintillation camera imaging of 15 adult subjects presenting no history of lung disease using a radioaerosol with an aerodynamic diameter 0.5 ..mu..m(sigmag=1.50). Pulmonary function measurements and the radioaerosol procedure were conducted in each patient on at least two separate occasions. FVC, FEVl and airway resistance was measured pre and post monitored breathing of room air (30 min) and a subsequent aerosol clearance procedure was conducted as a baseline study; the same procedures were repeated after three or more days with 0.5 ppm ozone substituted for room air. The major observations from the clearance studies and the pulmonary function tests include: 1) no significant changes were detected between the baseline and ozone pulmonary function tests, 2) ROI analyses of the 30 min clearance data show no significant changes in the average Tc-99m DTPA clearance between the baseline room air (t1/2=85+-30 min) and ozone (t1/2=83+-24min) inhalation studies, and, 3) despite consistent average clearance rates, 7/15 subjects showed large changes in clearance (..delta..=24-72 min) and functional mapping showed major shifts in distribution in 5/15 subjects after ozone inhalation. The apparent high sensitivity, yet somewhat disparate observations, support the need of further investigation of factors influencing radioaerosol for the study of lung epithelial permeability.
- Research Organization:
- Univ. of Rochester School of Medicine and Dentistry, Rochester, NY
- OSTI ID:
- 6698207
- Report Number(s):
- CONF-850611-; TRN: 87-015352
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
LUNGS
DYNAMIC FUNCTION STUDIES
SCINTISCANNING
OZONE
BIOLOGICAL EFFECTS
MONITORING
RADIOACTIVE AEROSOLS
LUNG CLEARANCE
ADULTS
AEROSOLS
AIR POLLUTION MONITORING
CAMERAS
DTPA
FLOW RATE
IMAGE SCANNERS
INHALATION
MEASURING METHODS
PATIENTS
PERMEABILITY
RESPIRATORY SYSTEM DISEASES
SENSITIVITY
TECHNETIUM 99
TIME DEPENDENCE
AGE GROUPS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
DRUGS
EXCRETION
HOURS LIVING RADIOISOTOPES
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
SOLS
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
560300* - Chemicals Metabolism & Toxicology
550601 - Medicine- Unsealed Radionuclides in Diagnostics