Male reproductive function in long-term survivors of childhood cancer

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Med. Pediatr. Oncol.; (United States)

DOI:https://doi.org/10.1002/mpo.2950160404· OSTI ID:6687631

Jaffe, N; Sullivan, M P; Ried, H; Boren, H; Marshall, R; Meistrich, M; Maor, M; da Cunha, M

We evaluated reproductive function in 27 male long-term survivors of childhood cancer treated during the prepubertal and pubertal period. Sperm samples were obtained from 23 patients; four who refused to provide specimens indicated that they had fathered normal healthy children. Thirteen patients were 12 years old or younger at the time of diagnosis and initiation of therapy. Chemotherapy was calculated according to the cumulative amount of drug administered and correlated with the surface area. Sterility was associated with large doses of single alkylating agents or reduced doses administered with other agents in combination regimens. It was noted in boys treated in both the prepubertal and pubertal period. Sterility was also observed in patients who received testicular radiation alone or in combination with chemotherapy. However, it was not an inevitable consequence in all patients, despite treatment with similar or identical regimens. Fertility potential could not be predicted by clinical examination (testicular size) or gonadotrophin and testosterone values. The results were compared to published reports of treatment-induced sterility in adult males. Additional investigations are required to establish more accurate correlations of dosage with reproductive potential.

• Research Organization: Univ. of Texas, Houston (USA)
• OSTI ID: 6687631
• Journal Information: Med. Pediatr. Oncol.; (United States), Vol. 16:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
RADIOTHERAPY
SIDE EFFECTS
STERILITY
RADIOINDUCTION
TESTES
DELAYED RADIATION EFFECTS
CHEMOTHERAPY
DYNAMIC FUNCTION STUDIES
FSH
LH
NEOPLASMS
PATIENTS
REPRODUCTION
TESTOSTERONE
ANDROGENS
ANDROSTANES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
GONADOTROPINS
GONADS
HORMONES
HYDROXY COMPOUNDS
KETONES
MALE GENITALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIOLOGY
STEROID HORMONES
STEROIDS
THERAPY
560151* - Radiation Effects on Animals- Man