Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells

Journal Article · Sat Jul 01 00:00:00 EDT 1978 · J. Exp. Med.; (United States)

DOI:https://doi.org/10.1084/jem.148.1.103· OSTI ID:6663208

Bellgrau, D; Wilson, D B

The present studies extend our previous efforts to understand the immunological basis of specifically induced graft-versus-host (GVH) resistance in F1 hybrid rats. Immunization of F1 rats with alloreactive T-cell populations of parental strain origin induces a host-mediated T-cell response which is specific for anti-major protective immunity is rapid in onset and once induced, it provides a highly effective, specific resistance to lethal GVH disease which is radioresistant and can be adoptively transferred to syngeneic recipients.

• Research Organization: Univ. of Pennsylvania, Philadelphia, PA (United States)
• OSTI ID: 6663208
• Journal Information: J. Exp. Med.; (United States), Vol. 148:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GRAFT-HOST REACTION
IMMUNOLOGY
ANTIBODIES
ANTIGENS
BIOLOGICAL RADIATION EFFECTS
DISEASES
HYBRIDIZATION
RATS
ANIMALS
BIOLOGICAL EFFECTS
MAMMALS
RADIATION EFFECTS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals