Late effects of treatment of cancer in infancy
Eighty-six children were diagnosed with cancer in infancy, followed for at lest 5 years, and assessed for late effects of disease and therapy. One child subsequently died from respiratory failure and 3 died from second primary cancers. Another patient survived second primary cancers of the skin. The high frequency of new cancers (4 observed, 0.09 expected) was attributable to host susceptibility factors and treatment effects. Kyphoscoliosis was diagnosed in 44 patients, 40 of whom had received radiotherapy to the spine. Other patients had neurologic deficits, pulmonary fibrosis, hypoplastic breasts, bowel adhesions, thyroid nodules, musculoskeletal defects, and liver fibrosis associated with tumor therapy. Sequelae of cancer were more common after treatment in infancy than in later childhood. Improved treatments and knowledge of natural history can reduce adverse effects of therapy.
- Research Organization:
- Division of Biostatistics and Epidemiology, Sidney Farber Cancer Institute, Boston
- OSTI ID:
- 6655343
- Journal Information:
- Med. Pediatr. Oncol.; (United States), Vol. 10:4
- Country of Publication:
- United States
- Language:
- English
Similar Records
Radiation-associated thyroid carcinoma
Radiation-associated thyroid carcinoma
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LIVER
DELAYED RADIATION EFFECTS
LUNGS
MAMMARY GLANDS
RADIOTHERAPY
SIDE EFFECTS
SKIN
THYROID
VERTEBRAE
CHILDREN
FIBROSIS
PATIENTS
RADIOINDUCTION
SKIN DISEASES
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE GLANDS
GLANDS
MEDICINE
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOLOGY
RESPIRATORY SYSTEM
SKELETON
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man