Human somatostatin receptor genes: Localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms

Journal Article · Mon Feb 01 00:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1088· OSTI ID:6652814

Yamada, Y; Stoffel, M; Espinosa, R III; Xiang, Kunsan; Seino, Mitsuko; Seino, Susumu; Beau, M le; Bell, G I ^[1]

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1. Univ. of Chicago, IL (United States)

The genes encoding three different human somatostatin receptor subtypes, designated SSTR1, SSTR2, and SSTR3, were mapped to chromosomes 14, 17, and 22, respectively, by analyzing their segregation in a panel of reduced human-hamster somatic cell hybrids. These assignments were confirmed independently using fluorescence in situ hybridization to metaphase chromosomes and the genes were further localized to 14q13,17q24, and 22q1.31, respectively. Highly informative simple tandem repeat DNA polymorphisms were identified in SSTR1 and SSTR2. 4 refs., 1 fig., 1 tab.

• OSTI ID: 6652814
• Journal Information: Genomics; (United States), Vol. 15:2; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HUMAN CHROMOSOME 14
GENETIC MAPPING
HUMAN CHROMOSOME 17
HUMAN CHROMOSOME 22
RECEPTORS
GENES
SOMATOSTATIN
DNA
FLUORESCENCE
HYBRIDIZATION
SEGREGATION
CHROMOSOMES
HUMAN CHROMOSOMES
LUMINESCENCE
MAPPING
MEMBRANE PROTEINS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PROTEINS
550400* - Genetics