Model for bile salt micellization and solubilization from studies of a [open quotes]polydisperse[close quotes] array of fluorescent probes and molecular modeling
- Duke Univ., Durham, NC (United States)
The micellar aggregation of the bile salt sodium taurocholate (NaTC) in water, in the concentration range 0-35 mM, was studied by using a [open quotes]polydisperse[close quotes] array of polycyclic aromatic hydrocarbon probes, ranging from pyrene with four aromatic rings to ovalene with 10 aromatic rings. Measurements of fluorescence spectra, peak intensity, vibronic band intensity ratio, and lifetime were used to follow the solubilization of the probes as a function of NaTC concentration. The results strongly support stepwise aggregation behavior since at least two critical regions of NaTC concentration were reported by each of the probes. For all probes, one of these critical regions occurs at 8-12 mM. The other critical concentration regions, referred to as [open quotes]apparent critical micellar concentrations[close quotes] (acmc), increase with increasing probe size and include 4, 15, and 20 mM. 27 refs., 9 figs., 5 tabs.
- OSTI ID:
- 6649474
- Journal Information:
- Journal of Physical Chemistry; (United States), Vol. 98:51; ISSN 0022-3654
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
POLYCYCLIC AROMATIC HYDROCARBONS
DISSOLUTION
FLUORESCENCE SPECTROSCOPY
AQUEOUS SOLUTIONS
BIOLOGICAL MATERIALS
COMPILED DATA
COMPUTERIZED SIMULATION
LIFETIME
MICELLAR SYSTEMS
PROBES
PYRENE
SALTS
SODIUM COMPOUNDS
ALKALI METAL COMPOUNDS
AROMATICS
CONDENSED AROMATICS
DATA
DISPERSIONS
EMISSION SPECTROSCOPY
HYDROCARBONS
INFORMATION
MATERIALS
MIXTURES
NUMERICAL DATA
ORGANIC COMPOUNDS
SIMULATION
SOLUTIONS
SPECTROSCOPY
550200* - Biochemistry
400201 - Chemical & Physicochemical Properties
990200 - Mathematics & Computers