Influence of zinc on growth and development and on energy intakes of children with chronic renal failure

Thesis/Dissertation · Tue Jan 01 00:00:00 EST 1985

OSTI ID:6647517

Hagan, D W

This investigation assessed whether zinc acetate supplementation (2 mg/kg BW, maximum 40 mg/ka/child) in Children with End Stage Renal Disease, improved energy intakes and, in turn, growth and development. Height, weight, mid-arm circumference, triceps fatfold, hand wrist radiographs, and Tanner Staging measurements were taken at the beginning of the study, prior to zinc supplementation, and at the end of the study period. Clinical analyses for serum sodium, chloride, potassium, calcium, phosphorus, magnesium, alkaline phosphatase, total protein, albumin, blood urea nitrogen, creatinine, and CO/sub 2/ were routinely completed monthly. Simultaneously, plasma zinc and copper and erythrocyte zinc and 3 day food diaries were completed. Mean growth velocity in males was 4.07 +/- 2.02 cm/yr (non-supplemented), 2.98 +/- 2.33 cm/yr (supplemented) and in females, 3.88 +/- 0.73 cm/yr (non-supplemented), 3.28 +/- 2.10 cm/yr (supplemented). There were no significant differences between the supplemented and non-zinc supplemented males or females in growth velocity. Bone maturation as determined through hand wrist radiographs, improved in 4 of 6 zinc supplemented subjects. Before zinc supplementation, 50%, 92%, and 42% of the subjects met 67% of their RDA for age and sex for energy, protein, and zinc, respectively. After zinc acetate supplementation, the percentage of subjects meeting 67% of the RDA for energy, protein, and dietary zinc were 67%, 100%, and 67%, respectively. There was a trend toward increased dietary energy, protein, and zinc intake with zinc acetate supplementation.

• Research Organization: Michigan State Univ., East Lansing (USA)
• OSTI ID: 6647517
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHILDREN
GROWTH
ZINC
BIOLOGICAL EFFECTS
ALBUMINS
ALKALINE PHOSPHATASE
BLOOD PLASMA
BONE TISSUES
CALCIUM
CARBON DIOXIDE
CHLORIDES
COPPER
CREATININE
DIET
ERYTHROCYTES
KIDNEYS
MAGNESIUM
METABOLISM
NEPHRITIS
PHOSPHORUS
POTASSIUM
PROTEINS
SODIUM
UREA
AGE GROUPS
ALKALI METALS
ALKALINE EARTH METALS
AMIDES
ANIMAL TISSUES
AZOLES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBON COMPOUNDS
CARBON OXIDES
CARBONIC ACID DERIVATIVES
CHALCOGENIDES
CHLORINE COMPOUNDS
CONNECTIVE TISSUE
DISEASES
ELEMENTS
ENZYMES
ESTERASES
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC COMPOUNDS
HYDROLASES
IMIDAZOLES
IMINES
MATERIALS
METALS
NONMETALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHOSPHATASES
TISSUES
TRANSITION ELEMENTS
UROGENITAL SYSTEM DISEASES
551000* - Physiological Systems