Accidental ingestion of Tc-99m in breast milk by a 10-week-old child. [Whole-body and thyroid doses to infant 4 hrs after iv administration to mother]

Journal Article · Tue Aug 01 00:00:00 EDT 1978 · J. Nucl. Med.; (United States)

OSTI ID:6589370

Rumble, W F; Aamodt, R L; Jones, A E; Henkin, R I; Johnston, G S

Ten weeks after the birth of her first child by Caesarian section, a 27-year-old woman was admitted for evaluation of a possible central nervous system lesion. Four hours after iv administration of 15 mCi of Tc-99m for a brain scan, the patient breast-fed her infant; then became concerned about the possibility of radioactivity in her breast milk. Total body gamma-ray measurements of the infant indicated ingestion of 82.5 ..mu..Ci Tc-99m (corrected for effective T/sub 1/2/), while ingestion calculated from gamma-ray measurements of serial milk samples was 75.6 ..mu..Ci. The single organ radiation dose for the thyroid as the critical organ was 300 mrad, whereas that to the total body was 12 mrad (values derived from 82.5 ..mu..Ci determined by whole body counting). Had breast feeding been continued at 4-hr intervals, the total ingested activity would have been 94.8 ..mu..Ci giving the infant a dose of 380 mrad to the thyroid and 16 mRad to the whole body. Had the feeding been given 1/2-hr after injection, 726 ..mu..Ci would have been ingested, increasing the dose by a factor of 10.

• Research Organization: National Institutes of Health, Bethesda, MD
• OSTI ID: 6589370
• Journal Information: J. Nucl. Med.; (United States), Vol. 19:8
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
INFANTS
RADIATION DOSES
LACTATION
RADIONUCLIDE KINETICS
MILK
CONTAMINATION
TIME DEPENDENCE
TECHNETIUM 99
INGESTION
INTRAVENOUS INJECTION
WOMEN
BODY
BRAIN
ISOMERIC NUCLEI
PATIENTS
SCINTISCANNING
THYROID
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
CHILDREN
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DOSES
ENDOCRINE GLANDS
FEMALES
FOOD
GLANDS
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
NEONATES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
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