Epithelial carcinoma of the ovary
- M.D. Anderson Hospital and Tumor Inst., Houston, TX
A total of 176 patients with untreated epithelial cancer of the ovary received postoperative irradiation at the Alice Crocker Lloyd Radiation Therapy Center of the University of Michigan from 1955 to 1973. Irradiation was delivered to the pelvis alone or to the pelvis and part of the abdomen, depending on the extent of the disease and the location of the residual tumor. No patient received whole abdominal irradiation. Post-irradiation chemotherapy was administered to patients with advanced disease. Twenty-six patients with Stage III disease were treated according to a protocol consisting of pre- and post-irradiation administration of chlorambucil. The overall 5-year actuarial survival rate was 42%. The 5-year survival rates for patients with Stage I through IV disease were 77%, 31%, 23%, and 0% respectively. Patients whose tumor was grossly removed at the initial surgery did better (63% 5-year survival rate) than patients whose tumor was only partially removed (26% 5-year survival rate). The pathologic grade of the tumor was a major factor determining the prognosis. The 5-year survival rates were 76% for patients with well-differentiated carcinomas, 33% for those with moderately differentiated carcinomas, and 14% for those with poorly differentiated carcinomas. Thirty-four (20%) of the patients were found to have at least a second primary tumor either at the time of the initial surgery or some other time. Autopsy results for 25 patients in this series are presented.
- OSTI ID:
- 6579219
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 7:12
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARCINOMAS
BIOLOGICAL RADIATION EFFECTS
CHEMOTHERAPY
EVALUATION
RADIOTHERAPY
CHLORAMBUCIL
OVARIES
PATIENTS
PELVIS
SURGERY
SURVIVAL TIME
AMINES
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CARBOXYLIC ACIDS
DISEASES
DRUGS
FEMALE GENITALS
GONADS
MEDICINE
MONOCARBOXYLIC ACIDS
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine