Physiological responses of healthy human subjects consequent to inhalation of NO/sub 2/, O/sub 3/, and NO/sub 2/ plus 03 during heavy, sustained exercise. Final report, 9 November 1984-9 November 1986
The main goal of this project was to study the role of exercise and gender in a person's sensitivity to the effects of nitrogen dioxide, ozone, or a combination of the two pollutants. Healthy young adult subjects engaged in 60 minutes of heavy bicycle ergometer exercise while inhaling pollutants through a mouthpiece. Major findings were: heavy exercise does not seem to increase subject sensitivity to inhaled NO/sub 2/ (0.6 ppm) or to a combination of NO/sub 2/ and O/sub 3/ (0.3 ppm) with respect to the parameters that were measured (pulmonary function tests, symptoms, and exercise ventilatory pattern); inflammation and neural responses are important underlying factors in the response to O/sub 3/ as measured by the above parameters; women and men, when exercising at the same relative instensity, do not show gender based differences in sensitivity to the effects of O/sub 3/, NO/sub 2/, or a combination of the two pollutants; duration of enhanced responsiveness upon reexposure to O/sub 3/ (0.35 ppm) appears to last up to 48 hours with variation between individuals; and prior exposure to O/sub 3/ (0.3 ppm) does not affect the response to NO/sub 2/ (0.6 ppm) or to a combination of NO/sub 2/ and O/sub 3/ over that which can be attributed to O/sub 3/ alone.
- Research Organization:
- California Univ., Davis (USA). Human Performance Lab.
- OSTI ID:
- 6544373
- Report Number(s):
- PB-87-165106/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
AIR POLLUTION
EXERCISE
NITROGEN OXIDES
BIOLOGICAL EFFECTS
OZONE
ATROPINE
RESPIRATION
ALKALOIDS
AUTONOMIC NERVOUS SYSTEM AGENTS
CHALCOGENIDES
DRUGS
NITROGEN COMPOUNDS
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PARASYMPATHOLYTICS
POLLUTION
560300* - Chemicals Metabolism & Toxicology
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)