Higher density of serotonin-1A receptors in the hippocampus and cerebral cortex of alcohol-preferring P rats
- Lilly Research Laboratories, Indianapolis, IN (USA)
- Indiana Univ., Indianapolis (USA)
Saturable ({sup 3}H)-80HDPAT binding to 5HT-1A receptors in membranes prepared from hippocampus and frontal cerebral cortex of alcohol-preferring (P) rats and of alcohol-nonpreferring (NP) rats has been compared. The B{sub max} values or densities of recognition sites for 5HT-1A receptors in both brain areas of the P rats are 38 and 44 percent lower in the P rats than in the NP rats. The corresponding K{sub D} values are 38 and 44 percent lower in the P rats than in the NP rats, indicating higher affinities of the recognition sites for the 5HT-1A receptors in hippocampus and cerebral cortex of the P rats. These findings indicate either an enrichment of 5HT-1A receptor density during selective breeding for alcohol preference or an upregulation of 5HT-1A receptors of 5HT found in these brain areas of P rats as compared with the NP rats.
- OSTI ID:
- 6528538
- Journal Information:
- Life Sciences; (USA), Vol. 46:3; ISSN 0024-3205
- Country of Publication:
- United States
- Language:
- English
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