Gastric emptying and small intestinal transit in the piebald mouse model for Hirschsprung's disease

Journal Article · Wed Aug 01 00:00:00 EDT 1984 · Gastroenterology; (United States)

OSTI ID:6471096

Cooke, H J; Pitman, K; Starr, G; Wood, J D

Gastric emptying and small intestinal transit were investigated in the piebald mouse model for Hirschsprung's disease. These mice exhibited aganglionosis of the terminal segment of the large intestine. This condition was accompanied by fecal stasis and megacolon. Gastric emptying of saline or milk meals was slower in the mice with aganglionic or induced megacolon than in the normal mice, but the rate of emptying was faster than after administration of morphine (10 mg/kg). In the small intestine, the distribution of the radiolabeled marker and the advancing edge of the marker profile were abnormal in the mice with megacolon. There were small differences between the megacolonic and normal mice in the distance traversed by the advancing edge of the intraluminal profile of the marker. These results are evidence for disturbances of gastric and small intestinal motor function that occur in mice secondary to development of megacolon.

• Research Organization: Univ. of Nevada, Reno
• OSTI ID: 6471096
• Journal Information: Gastroenterology; (United States), Vol. 87:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LARGE INTESTINE
GANGLIONS
NERVOUS SYSTEM DISEASES
PATHOLOGY
SMALL INTESTINE
CHROMIUM ISOTOPES
DIGESTIVE SYSTEM DISEASES
EXCRETION
MICE
SYMPTOMS
ANIMALS
BODY
CLEARANCE
DIGESTIVE SYSTEM
DISEASES
GASTROINTESTINAL TRACT
INTESTINES
ISOTOPES
MAMMALS
NERVOUS SYSTEM
ORGANS
RODENTS
VERTEBRATES
550901* - Pathology- Tracer Techniques