Effect of hematocrit and systolic blood pressure on cerebral blood flow in newborn infants
The effects of hematocrit and systolic blood pressure on cerebral blood flow were measured in 15 stable, low birth weight babies. CBF was measured with a modification of the xenon-133 (/sup 133/Xe) clearance technique, which uses an intravenous bolus of /sup 133/Xe, an external chest detector to estimate arterial /sup 133/Xe concentration, eight external cranial detectors to measure cephalic /sup 133/Xe clearance curves, and a two-compartmental analysis of the cephalic /sup 133/Xe clearance curves to estimate CBF. There was a significant inverse correlation between hematocrit and CBF, presumably due to alterations in arterial oxygen content and blood viscosity. Newborn CBF varied independently of systolic blood pressure between 60 and 84 mm Hg, suggesting an intact cerebrovascular autoregulatory mechanism. These results indicate that at least two of the factors that affect newborn animal CBF are operational in human newborns and may have important clinical implications.
- Research Organization:
- Univ. of Pennsylvania, Philadelphia
- OSTI ID:
- 6468181
- Journal Information:
- J. Cereb. Blood Flow Metab.; (United States), Vol. 3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BRAIN
BLOOD FLOW
BLOOD COUNT
BLOOD PRESSURE
CLEARANCE
DYNAMIC FUNCTION STUDIES
HOMEOSTASIS
INFANTS
TRACER TECHNIQUES
XENON 133
AGE GROUPS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
CHILDREN
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
XENON ISOTOPES
551001* - Physiological Systems- Tracer Techniques