Effects of short- and long-term exposure to ozone on heart rate and blood pressure of emphysematous rats
Electrocardiogram and arterial blood pressure of elastase-treated emphysematous rats (E rats) and saline-treated control rats (S rats) were recorded continuously during exposure to either 1 ppm ozone (O/sub 3/) for 3 hr or 0.5 ppm O/sub 3/ for 6 hr. The heart rates (HRs) of both groups decreased to about 50 and 65% of the initial levels at the end of 1 ppm and 0.5 ppm O/sub 3/ exposure, respectively. Mean arterial blood pressures (MAPs) also decreased to about 76 and 82%, respectively. There was no significant difference in these responses between E and S rats, although the levels of HRs and MAPs of the E rats were always a little lower than those of the S rats. Another group of E and S rats was continuously exposed to 0.2 ppm O/sub 3/ for 4 weeks. The HRs of both E and S groups decreased to about 81 and 88% of the initial levels on the first day, respectively, although they recovered completely by the third day. No significant difference in the variation of HRs during exposure was noted between E and S rats. However, the HR responses of these rats to a challenge exposure of 0.8 ppm O/sub 3/ for 1.5 hr appeared to be different. That is, S rats were more tolerant of the challenge exposure to O/sub 3/ for 1.5 hr than the E rats.
- Research Organization:
- Institute of Public Health, Tokyo (Japan)
- OSTI ID:
- 6459339
- Journal Information:
- Environ. Res.; (United States), Vol. 48:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
EMPHYSEMA
PATHOGENESIS
OZONE
TOXICITY
BLOOD PRESSURE
ELECTROCARDIOGRAMS
RATS
ANIMALS
DIAGRAMS
DISEASES
MAMMALS
RESPIRATORY SYSTEM DISEASES
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology