Toxicokinetics of nickel in rats after intratracheal administration of a soluble and insoluble form

Journal Article · Wed Jul 01 00:00:00 EDT 1981 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668191420125· OSTI ID:6453651

English, J C; Parker, R D.R.; Sharma, R P; Oberg, S G

Ninety day laboratory studies were performed to determine the whole body distribution of two chemical forms of nickel in female Wistar rats. A single injection of 15 ..mu..Ci of /sup 63/Ni, either NiCl/sub 2/ as a solution or NiO as a suspension. 100 nmoles in each case, was administered intratracheally. Rats were sacrificed at post-exposure intervals of 0.5, 2, and 8 hours, 1, 3, 7, 15, 30, 60 and 90 days, and major organs and tissues were analyzed for /sup 63/Ni by liquid scintillation counting technique. The soluble NiCl/sub 2/ was readily distributed throughout the body, and rapidly cleared from the tissues. The insoluble NiO was distributed slowly to other organs from pulmonary tissues. The rate of decline of /sup 63/Ni from various organs in the case of NiO was similar to that of NiCl/sub 2/, with notable exceptions being the lung and associated lymph nodes. After NiO administration, these organs showed a high retention of nickel after 90 days. Results indicated that Ni in soluble form was rapidly absorbed from the site of deposition following pulmonary exposure, whereas, Ni in its oxide or insoluble form was retained in lungs and related lymphatics for a considerable period. The amount of Ni in other organs following NiO exposure, though initially low in all tissues, declined in a fashion similar to organs following NiCl/sub 2/ exposure. This suggests that NiO was possibly converted to a soluble form of Ni before it was translocated from lungs to other organs, and that low environmental levels of insoluble forms of nickel, which persist in the lung and lymph nodes, do have the potential for assimilation in these tissues.

• Research Organization: Utah State Univ., Logan
• OSTI ID: 6453651
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Vol. 42:7
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
NICKEL
METABOLISM
BIOCHEMICAL REACTION KINETICS
DEPOSITION
INJECTION
LUNGS
LYMPHATIC SYSTEM
NICKEL 63
NICKEL CHLORIDES
NICKEL OXIDES
RATS
RETENTION
SCINTILLATION COUNTERS
SOLUBILITY
SOLVENT PROPERTIES
TISSUE DISTRIBUTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHALCOGENIDES
CHLORIDES
CHLORINE COMPOUNDS
DISTRIBUTION
ELEMENTS
EVEN-ODD NUCLEI
HALIDES
HALOGEN COMPOUNDS
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
KINETICS
MAMMALS
MEASURING INSTRUMENTS
METALS
NICKEL COMPOUNDS
NICKEL ISOTOPES
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIATION DETECTORS
RADIOISOTOPES
REACTION KINETICS
RESPIRATORY SYSTEM
RODENTS
TRANSITION ELEMENT COMPOUNDS
TRANSITION ELEMENTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550301 - Cytology- Tracer Techniques