Argonne-Utah studies of /sup 224/Ra endosteal surface dosimetry
The activities of /sup 212/Pb relative to /sup 224/Ra and of /sup 222/Rn relative to /sup 226/Ra were measured in bone surface deposits 24 h after radium injection into beagles. The fractional retention of /sup 220/Rn atoms was measured in vitro with hydrated and dehydrated bone samples to determine the effect of water content on the escape of radon from bone surfaces. The experimental data suggest that substantial /sup 224/Ra daughter product disequilibrium exists in bone surface deposits. Estimates for the lower and upper limits on the fractional retention of /sup 220/Rn in vivo are 0.05 and 0.25, respectively. The average bone surface activity of /sup 212/Pb relative to /sup 224/Ra ranged from 0.34 to 0.71 for four dogs, with the majority of the values toward the low end of the range. Only a small portion of the deposited /sup 212/Pb came from lead in the injection solution despite near equilibrium between /sup 224/Ra and its daughters at the time of injection. The retention data indicate that the endosteal tissue dose rate in the dogs at one day was actually one-third to about one-half that which would be calculated assuming equilibrium of /sup 224/Ra daughter products in bone surface deposits. 11 references, 2 figures, 7 tables.
- Research Organization:
- Argonne National Lab., IL (USA); Utah Univ., Salt Lake City (USA). Dept. of Pharmacology
- DOE Contract Number:
- W-31-109-ENG-38
- OSTI ID:
- 6448527
- Report Number(s):
- CONF-8410147-3; ON: DE85002761
- Resource Relation:
- Conference: Radiobiology of radium and thorotrast conference, Neuherberg, F.R. Germany, 29 Oct 1984
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE TISSUES
DOSIMETRY
RADIONUCLIDE KINETICS
RADON 220
RETENTION
BEAGLES
DOSE RATES
EXPERIMENTAL DATA
ISOTOPE RATIO
LEAD 212
MOISTURE
QUANTITY RATIO
RADIUM 224
RADIUM 226
RADON 222
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CONNECTIVE TISSUE
DATA
DAYS LIVING RADIOISOTOPES
DOGS
EVEN-EVEN NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INFORMATION
ISOTOPES
LEAD ISOTOPES
MAMMALS
NUCLEI
NUMERICAL DATA
RADIOISOTOPES
RADIUM ISOTOPES
RADON ISOTOPES
SECONDS LIVING RADIOISOTOPES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)