Comparative effects of aspirin and enteric-coated aspirin on loss of chromium 51-labeled erythrocytes from the gastrointestinal tract

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Clin. Ther.; (United States)

OSTI ID:6441664

Robbins, D C; Schwartz, R S; Kutny, K; Vallejo, G; Horton, E S; Cotter, J M

Sodium chromate Cr 51 was used to label red blood cells of 19 healthy male volunteers, whose stools were collected for four days before and four days during oral administration of either uncoated (N . 9) or enteric-coated (N . 10) aspirin. Each subject received 2.925 gm/day of aspirin, in three equal doses separated by eight-hour intervals, for a total of seven days. During drug use, stools were collected on days 4 through 7. Fecal blood content, estimated by measuring radioactivity in the stools, was significantly higher (P less than 0.001) during use of either type of aspirin than at baseline, but losses measured during use of the coated aspirin (mean, 1.54 ml/day) were significantly lower (P less than 0.001) than those measured during use of the uncoated aspirin (mean, 4.33 ml/day). The two types of aspirin produced equivalent serum concentrations of salicylates. We conclude that enteric-coated aspirin reduces gastrointestinal blood loss.

• Research Organization: Department of Medicine, University of Vermont College of Medicine, Burlington
• OSTI ID: 6441664
• Journal Information: Clin. Ther.; (United States), Vol. 6:4
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ACETYLSALICYLIC ACID
BIOLOGICAL EFFECTS
ERYTHROCYTES
LOSSES
CHROMIUM 51
FECES
INGESTION
LABELLED COMPOUNDS
MAN
RESPONSE MODIFYING FACTORS
TRACER TECHNIQUES
ANALGESICS
ANIMALS
ANTIPYRETICS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHROMIUM ISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HYDROXY ACIDS
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
RADIOISOTOPES
VERTEBRATES
WASTES
551001* - Physiological Systems- Tracer Techniques