Intestinal absorption and secretion of radioactive vanadium (/sup 48/VO/sup -//sub 3/) in rats and effect of Al(OH)/sub 3/

Journal Article · Sun Aug 01 00:00:00 EDT 1982 · J. Toxicol. Environ. Health; (United States)

OSTI ID:6374357

Wiegmann, T B ^[1]; Day, H D; Patak, R V

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1. Univ. of Kansas Medical Center, Kansas City

Sprague-Dawley rats (180-300 g) were fasted overnight and gavaged with 5 ..mu..mol Na/sub 3/VO/sub 4/ in 1.0 ml 0.9% NaCl containing 1 ..mu..Ci /sup 48/V. Control animals (n = 12) simultaneously received 1.0 ml diluent and experimental animals (n = 12) received 1 ml Al(OH)/sub 3/. Diluent and Al(OH)/sub 3/ were then given daily for 4 d. Urine and feces were collected separately each day. In control animals total /sup 48/V recovery (stool and urine) over 4 d was 86.6 +/- 2.4% of the administered dose. Although Al(OH)/sub 3/ insignificantly increased total /sup 48/V recovery (93.6 +/- 3.2%), it markedly increased excretion of /sup 48/V in the stool as compared to the urine (control:stool, 69.1 +/- 1.8%; urine, 12.5 +/- 1.3%; Al(OH)/sub 3/:stool, 85.7 +/- 1.5%; urine, 7.9 +/- 1.8%). Animals were then sacrificed and tissue uptake of tracer measured. The pattern of unexcreted /sup 48/V in tissues of both groups was kidney > bone > liver > intestine > muscle, but the tissue levels were uniformly higher in controls than in Al(OH)/sub 3/-treated animals. The ability of Al(OH)/sub 3/ to remove endogenous VO/sup -//sub 3/ was also examined. /sup 48/V was injected ip (n = 20). Half of the animals received diluent and half received 1.0 ml Al(OH)/sub 3/ by gavage daily for 4 d. There were no differences in the pattern of /sup 48/V tissue distribution and excretion. It is concluded that Al(OH)/sub 3/ may prevent tissue accumulation of VO/sup -//sub 3/ from dietary sources by reducing intestinal VO/sup -//sub 3/ absorption. (JMT)

• OSTI ID: 6374357
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 10:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALUMINIUM HYDROXIDES
BIOLOGICAL EFFECTS
VANADIUM 48
EXCRETION
INTESTINAL ABSORPTION
TISSUE DISTRIBUTION
FECES
INGESTION
INTESTINES
INTRAPERITONEAL INJECTION
KIDNEYS
LIVER
MUSCLES
RATS
SKELETON
URINE
VANADATES
ABSORPTION
ALUMINIUM COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
GASTROINTESTINAL TRACT
GLANDS
HYDROGEN COMPOUNDS
HYDROXIDES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MATERIALS
NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPES
RODENTS
TRANSITION ELEMENT COMPOUNDS
UPTAKE
VANADIUM COMPOUNDS
VANADIUM ISOTOPES
VERTEBRATES
WASTES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)