Cholecystokinin cholescintigraphic findings in the cystic duct syndrome

Journal Article · Tue Oct 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6334826

Fink-Bennett, D; DeRidder, P; Kolozsi, W; Gordon, R; Rapp, J

Fourteen patients with a cystic duct syndrome (CDS) underwent cholecystokinin (CCK) cholescintigraphy. All patients presented with persistent postprandial right upper quadrant pain and biliary colic. None of the patients had an abnormal oral cholecystography, gallbladder (GB) ultrasound exam or upper GI series. Each patient received 5 mCi of technetium-99m disofenin. When the GB maximally filled, 0.02 microgram/kg CCK was administered (3 min) intravenously. Background corrected gallbladder ejection fractions (GBEFs) were determined every 5 min X 4 by rationing the pre-CCK GB counts minus post-CCK GB counts to pre-CCK GB counts. GBEFs were: 12% (3 patients), 17% (2), 0%, 1.3%, 3%, 4%, 6%, 11%, 14%, 18.5%, and 22% (1 each). All patients underwent a surgical exploration and all had macro- or microscopically abnormal cystic ducts with (12 patients) or without (2 patients) concomitant chronic cholecystitis. No patient with a partially occluded cystic duct with or without concomitant chronic cholecystitis had an ejection fraction that exceeded 22%. In an appropriate clinical setting, a low EF response to CCK should alert the physician to the presence of either chronic acalculous cholecystitis, CDS, or the combination of both.

• Research Organization: William Beaumont Hospital, Royal Oak, MI
• OSTI ID: 6334826
• Journal Information: J. Nucl. Med.; (United States), Vol. 10
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
BILIARY TRACT
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KININS
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TECHNETIUM 99
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550601* - Medicine- Unsealed Radionuclides in Diagnostics